Changes in ocular mucin expression due to contact lens wear

INTERVENTION: A prospective, randomised, contralateral lens wear, open label, single group design clinical trial. with participants wearing comercially available lenses (AIR OPTIX AQUA and PUREVISION) and lens care solution (AOSEPT PLUS). Lenses will be worn for one month and a minimum of 6 hours per day, 5 days per week, on a daily wear basis (i.e. removed prior to sleep). Lenses will be disinfected overnight (minimum of 6 hours) in the lens care solution. CONDITION: Contact lens wear affects mucin expression on the ocular surface and in tear fluid. The mucin change correlates with clinical variables and lens performance. PRIMARY OUTCOME: To investigate mucin changes due to contact lens wear using impression cytology to permit collection and morphological examination of the superficial layers of the superior tarsal conjunctival epithelium. Samples will be taken prior to lens wear (i.e. baseline visit) and following 1 month of lens wear. SECONDARY OUTCOME: To determine whether there is a correlation between mucin changes and clinical performance or comfort of commercially available contact lenses. Qestionnaires will be used to asess subjective performance. Objective assessment of the eyes wiill be conducted with a slit‐lamp biomicroscope (including corneal and conjunctival staining fluorecein). INCLUSION CRITERIA: Able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent; Willing to comply with the wearing and clinical trial visit schedule as directed by the Investigator; Have ocular health findings considered to be “normal” and which would not prevent the participant from safely wearing contact lenses; Has vision correctable to at least 6/12 (20/40) or better in each eye with contact lenses.