Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects.

Category Primary study
JournalJournal of affective disorders
Year 1990
The ratios of total and free plasma tryptophan to the sum of five large neutral amino acids (LNAAs) were found to be significantly lower in a group of 16 depressed inpatients compared to nine normal subjects after oral loading with L-tryptophan. The group differences in these ratios were significant before, and 2 weeks after starting treatment with a tricyclic antidepressant. Plasma tryptophan ratios and severity of depression were not significantly correlated.
Epistemonikos ID: 49540d4acfac5960d21cc9e7835ef4ef1fd567bc
First added on: May 14, 2022