Effect of Two Toothpastes on Bacteria in Saliva

This was a single centre, three treatment, randomized, blinded, cross‐over study which involved rinsing with slurries of two sodium fluoride‐silica dentifrices containing zinc chloride and sodium citrate, and with water alone. The study consisted of four Visits: Visit 1 (Screening), Visit 2 (Treatment 1), Visit 3 (Treatment 2), Visit 4 (Treatment 3). There was a minimum two days wash out period before the first treatment visit and between treatment visits to avoid any treatment carry‐over effect. During that time participants brushed as normal (twice‐daily) at home with a washout toothpaste and a toothbrush which was provided at screening. Participants were required not to brush their teeth on the morning of the treatment visits and not to eat or drink for 2 hours prior to the treatment visits.