The efficacy of ogikeishigomotsuto on chronic cumulative sensory neuropathy induced by Oxaliplatin : Case report and Literature view

Oxaliplatin (L-OHP) in combination with infusional 5-fluorourasil / Leucovorin (FOLFOX) has emerged as the treatment of choice for advanced, recurrent colorectal cancer, and its dose-limiting adverse effect is sensory neurotoxicity. We administered ogikeishigomotsuto (OKG: traditional herbal medicine, Kampo) to a patient with recurrence colon cancer with modified FOLFOX6 (mFOLFOX6), who subsequently demonstrated clinical improvement of L-OHP-induced neuropathy. A 59-year-old man with recurrent colon cancer was administered mFOLFOX6. During cycles 4, he complained of paresthesia in the distal extremities, which had been induced by L-OHP. To reduce the neurotoxicity of L-OHP, OKG was administered together along with the anticancer agents starting the 7th cycle. The severities of neurotoxicity before and after administration OKG were grade 2 and grade 1 based on the neurotoxicity criteria of DEBIOPHARM (DEB-NTC), respectively. This observation suggests that OKG may be useful agent to reduce or prevent chronic cumulative neurotoxicity due to L-OHP.