Comparison of two nebulized drugs on hemodynamic response to video laryngoscopy

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: Nebulized Dexmedetomidine: Each patient will receive 4mL Dexmedetomidine (1 mcg/kg) nebulized until the complete utilization of the drug (approximately 7 to 10 minutes), 40 minutes prior to induction of anaesthesia. Control Intervention1: Nebulized Lignocaine: Each patient will receive 4mL of Lignocaine (4%) nebulized until the complete utilization of the drug (approximately 7 to 10 minutes), 40 minutes prior to induction of anaesthesia. CONDITION: Health Condition 1: O‐ Medical and Surgical PRIMARY OUTCOME: To compare the systolic blood pressure immediately after intubation in Group D Dexmedetomidine versus Group L LignocaineTimepoint: Baseline and Immediately after intubation SECONDARY OUTCOME: Ancillary observations ; 1.Attempts of intubation ; 2.Duration of intubation ; 3.Rate pressure product immediately after intubation in both the groups. ; Timepoint: After surgery To compare between the two groups ; 1. Salivary alpha amylase levels ; Timepoint: At baseline and 5 minutes post intubation To compare between the two groups ; 1. Systolic blood pressure ; Timepoint: 2 minutes and 5 minutes after intubation ; To compare between the two groups ; 1.Consumption of propofol in mg for induction of anaesthesia. ; Timepoint: After surgery To compare between the two groups ; 1.Diastolic blood pressure ; 2.Mean arterial pressure ; 3.Heart rate ; Timepoint: At baseline, immedialtely after intubation, 2 minutes and 5 minutes after intubation. To compare between the two groups ; 1.Sedation in postoperative period ; Timepoint: 30 minutes after extubation. INCLUSION CRITERIA: 1.Consenting male or female aged 18‐60 years, ASA I and ASA II patients scheduled for surgery under general anaesthesia with endotracheal intubation.
Epistemonikos ID: 479ef43022ae8c7fe5663667254decaf7b539fb7
First added on: Oct 08, 2026