Authors
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[No authors listed]
Category
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Primary study
Registry of Trials»Iranian Registry of Clinical Trials
Year
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2011
INTERVENTION: At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Esmolol 0.5 mg/kg bolus dose for 4 min before extubation and then infusion of 0.15mg / kg/min of Esmolol until 10 min after extubation. At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive normal saline with the same volume and order of active drugs. At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Remifentanil 0.2µg/kg bolus dose for 4 min before extubation and then infusion of 0.1µg / kg/min of Remifentanil until 10 min after extubation. Intervention 1: At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Esmolol 0.5 mg/kg bolus dose for 4 min before extubation and then infusion of 0.15mg / kg/min of Esmolol until 10 min after extubation. Intervention 2: At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive normal saline with the same volume and order of active drugs. Intervention 3: At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Remifentanil 0.2µg/kg bolus dose for 4 min before extubation and then infusion of 0.1µg / kg/min of Remifentanil until 10 min after extubation. Placebo Prevention CONDITION: Condition 1: Heart rate changes due to Tracheal Extubation. Condition 2: Blood pressure changes due to Tracheal Extubation. ; Tachycardia, unspecified ; Elevated blood‐pressure reading, without diagnosis of hypertension Elevated blood‐pressure reading, without diagnosis of hypertension Tachycardia, unspecified PRIMARY OUTCOME: Dyastolic blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff. Extubation time. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices. Heart rate. Timepoint: Before extubation, after extubation, each 5 min until discharge from recovery. Method of measurement: continuous ECG monitoring. Mean arteial blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff. Oxygen saturation. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: pulse oxymetry devices. Systolic blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff. The time of discharg of recovery. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices. The time of opening of eyes. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices. SECONDARY OUTCOME: ECG changes. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: continuous ECG monitoring. INCLUSION CRITERIA: INCLUSION CRITERIA: Adult patients, belonging to ASA (American Society of Anesthesiologist) I and II Class, undergoing elective Intracranial Mass Lesions surgeries Exclusion criteria: Pregnancy, heart rate below 60 bpm, systolic blood pressure below 100 mmHg, serious hepatic, renal and cardiovascular diseases, congestive heart failure, atrioventricular block, sick sinus syndrome, drug allergy and past history of ß_blocher intolerance, bronchospasm, asthma, chronic obstructive pulmonary diseases
Epistemonikos ID: 478f7bda015161d47f8b30103df9778405f5fbb7
First added on: Aug 22, 2024