Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
The pathophysiology of restless legs syndrome (RLS) is not well understood: it is thought to involve intracerebral iron deficiency and dopaminergic dysregulation. This study aims to evaluate the use of intravenous ferric carboxymaltose in patients with restless legs syndrome (RLS). This study plans to include individuals with RLS, who will be divided into two groups: * One group will receive intravenous iron immediately after the baseline polysomnography * The second group will receive intravenous iron 3 months after randomization. In total, participants will be followed for 6 months, during which time they will be required to complete questionnaires regularly, undergo blood draws, and have two polysomnography tests.
Epistemonikos ID: 464fea423ba97c875aa71141be05bdf0b579c905
First added on: Sep 17, 2026