The Neural Mechanisms of Electroacupuncture for Major Depressive Disorder

Authors
Category Primary study
Registry of TrialsInternational Traditional Medicine Clinical Trial Registry
Year 2026
INTERVENTION: Electroacupuncture group:Electroacupuncture treatment;Sham acupuncture group:Non‐acupoint treatment;Waiting‐list group:No intervention; CONDITION: Major depressive disorder PRIMARY OUTCOME: Hamilton Depression Scale‐24 items; SECONDARY OUTCOME: Hamilton Anxiety Scale;Pittsburgh Sleep Quality Index;Patient Health Questionnare;Indicators of functional magnetic resonance imaging;Indicators of structural magnetic resonance imaging; INCLUSION CRITERIA: 1. A current diagnosis of major depressive disorder based on DSM‐V; 2. 18 to 60 years old; 3. Right‐hander; 4. The score of the 24‐item Hamilton Depression Rating Scale (HAMD‐24) is greater than 8 and less than 35; 5. No contraindications to magnetic resonance imaging (e.g., metallic implants, claustrophobia); 6. Psychotropic drug‐free‐period of at least three months; 7. Voluntarily participating in the research and signing of the informed consent form.
Epistemonikos ID: 457dee848a76cab154c2df9e6334dc9bc5e4d50f
First added on: Aug 10, 2026