Treatment of PCOS in Unani medicine

INTERVENTION: Intervention1: Majoon Dabidul Ward, Arq‐e Mako and Arq‐e Kasni: Majoon Dabidul Ward 6 gram twice daily, Arq‐e Mako 60 mL twice daily and Arq‐e Kasni 60 mL twice daily for 12 weeks Control Intervention1: Tablet Metformin 500 mg: Tablet Metformin 500 mg twice daily for 12 weeks CONDITION: Health Condition 1: E282‐ Polycystic ovarian syndrome PRIMARY OUTCOME: Change in HOMA‐IR from baseline to 12 weeks Calculated as Fasting Insulin (uIUmL) x Fasting Glucose (mmolL) per 22.5] ; Change in menstrual cycle frequency and regularity (assessed by validated menstrual diary and PALM‐COEIN classification of AUB)Timepoint: baseline, 4 weeks, 8 weeks and 12 weeks and 16 weeks SECONDARY OUTCOME: Change in HOMA‐IR from baseline to 12 weeks Calculated as Fasting Insulin (uIUmL) XFasting Glucose (mmolL) per 22.5] ; Change in menstrual cycle frequency and regularity (assessed by validated menstrual diary and PALM‐COEIN classification of AUB)Timepoint: baseline, and 12 weeks INCLUSION CRITERIA: Confirmed diagnosis of PCOS according to the Rotterdam Consensus Criteria (2003), requiring at least 2 of 3 criteria: HOMA‐IR value 2.5 or more at baseline screening. Presence of oligomenorrhoea (cycle interval more 35 days or amenorrhoea (absence of menstruation for more than 90 days) for at least 6 months. Willing to provide written informed consent and comply with study protocol for the entire duration. Not on any hormonal contraceptives or insulin sensitisers for a minimum of 3 months prior to enrolment