Prednisolone therapy of the first episode of idopatic nephrotic syndrome in children: A Multi-center randomized controlled trial

INTERVENTION: PSL for 2 months PSL for 6 months CONDITION: Idiopatic nephrotic syndrome in children PRIMARY OUTCOME: Time to frequent relapse INCLUSION CRITERIA: 1)The first episode of idiopathic nephrotic syndrome (proteinuria with a urinary protein‐creatinine ratio >1.8 and hypoalbuminemia with serum albumin level <2.5 g/dL). 2)Treated with predonisolone 60 mg/m2/day single daily dosing for 4 weeks. 3)Diagnosis of steroid sensitive NS has been performed within within the third week after the onset of PSL therapy. 4)Aged twelve months to 15 years. 5)Written informed consent from the patients' parents or legal guardians.