The role of ascorbic acid in the expression of miRNA and mood in patients with depression: A randomized controlled trial.

INTERVENTION: • In this randomized controlled trial, there will be two groups of patients suffering from depression. o Among these two groups one will be interventional group and one group will be the control group Interventional Group will be on antidepressants (conventional treatment and Ascorbic Acid 500mg orally daily once a day for three months CONDITION: Depression; ; Depression Mental Health ‐ Depression PRIMARY OUTCOME: Change in Hamilton depression rating scale.; [ Baseline and after three months of treatment] SECONDARY OUTCOME: Change in blood ascorbic acid levels.[ At baseline and after three months of treatment] Change in expression levels of microRNAs, miR‐132, miR‐182, miR‐124, miR‐let7b, miR‐let7C[ At baseline and after three months of treatment] INCLUSION CRITERIA: Patients with a total count of 16 or more on Hamilton Depression Rating Scale (HAM‐D) both men and women with an age limit between 18years to 45 years