Effect of combined therapy using balloon-ocluded arterial infusion of cisplatin with concurrent radiation for locally invasive bladder cancer: multi-center study

INTERVENTION: BOAI‐CDDP arterial infusion + radiation Dose: CDDP 100mg x 1 + radiation 60Gy follow up duration: 5 years Radical cystectomy with/without neoadjuvant or adjuvant chemotherapy CONDITION: bladder cancer PRIMARY OUTCOME: progression free survival INCLUSION CRITERIA: (1) patients who or whose family can agree with written informed consent (2) patients with bladder cancer which is histologivally comfirmed urothelial cancer (3) cTNM classification: T2‐T3, N0, M0 (4) performance status: PS 0‐2 (ECOG) (5) patients who meet the following criteria 1. liver function; AST less than 2.5 times of the institutional upper limit of the normal range, total bilirubin less than; 2.0 times of the institutional upper limit of the normal range, 2. renal function; creatinin less than 1.5mg/dL, 3.cardiac function; tolerable function for the therapy, 4. bone‐marrow; WBC more than 3,000/microL, neutrophil more than 1,500/microL, hemoglobin more than 10g/dL, platelet more than 100,000/microL, (6) regardless of age.