Combination of Yishen Granule and Acupuncture for older adults with mild cognitive impairment: a randomized controlled trial

Inclusion criteria: 1. Aged 65–85 years; 2. Complaint of allomnesia, which can be obtained from an informant who knows the patient well; 3. In addition to memory impairment, other cognitive functions are relatively intact or mildly impaired 4. The cognitive impairment is not severe enough to interfere with daily life; 5. Can't meet the diagnostic criteria for dementia; 6. Without other diseases which can cause brain disorder; 7. GDS score between 2‐3, CDR score=0.5, MMSE score>24, DRS score>123, memory test score<1.5 SD according to the age and education matched control group; 8. Able to understand and complete the scale evaluations; 9. Sign the written informed consent form. Exclusion criteria: 1. Participants who are assessed as normal or dementia by the CDR (Clinical Dementia Rating); 2. Participants with a HAMD (Hamilton Depression Scale) score>8; 3. Participants with schizophrenia, Schizoaffective Disorder, primary affective disorder (including the history of affective disorder), or Participants with severe neural disorder (such as aphasia or agnosia); 4. Participants who were diagnosed as AD, central nervous system infections, post traumatic dementia, toxic encephalopathy, metabolic encephalopathy, Huntington's disease, multiple sclerosis or Parkinson's disease before memory decline, or Participants with untreated primary endocrine disease; 5. Participants with severe primary disease of the cardiovascular, hepatic, renal, or hematopoietic system; 6. Participants suffering from gastrointestinal diseases that affect drug absorption (such as severe dyspepsia, gastrointestinal obstruction or Gastric ulcer); 7. Participants who are allergic to the study granule; 8. Participants who have taken Western and/or Oriental medicine in the past 2 weeks to improve the cognitive function; mild cognitive impairment Group A:acupuncture+Yishen Granule;Group B:acupuncture+placebo;Group C:sham acupuncture+Yishen Granule; Montreal Cognitive Assessment; Mini‐Mental State Examination;event‐related potential;