Effect of high fresh gas flow vs low fresh gas flow with higher dial concentration of sevoflurane during the wash-in phase on inhaled anesthetic agent consumption among adult surgical patients requiring general anesthesia- A Randomised controlled trial

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: Low fresh gas flow with higher dial concentration of sevoflurane: Following IV induction, in the HFGF group, fresh gas flow will be initially at 4L/min with the 2.5% dial concentration, using 50% FiO2 with O2:Air, while in the LFGF group, the fresh gas flow will be at 1L/min and 8% dial concentration, using 50% FiO2 with O2:Air. Control Intervention1: Conventional high fresh gas flow with low fresh gas flow of inhaled anaesthetic agent: Group A receives low fresh gas flow with higher dial concentration while group B receives high fresh gas flow with low dial concentration CONDITION: Health Condition 1: O‐ Medical and Surgical PRIMARY OUTCOME: Mean total anaesthetic agent consumption ; Time required to attain 1 minimum alveolar concentrations during wash‐in ; The hemodynamic parameters and bus pectoral index between 2 groupsTimepoint: Mean total anaesthetic agent consumption SECONDARY OUTCOME: Time required to achieve 1 minimum alveolar concentration of sevofluraneTimepoint: From initiation of the wash‐in phase till the attainment of 1 minimum alveolar concentration of sevoflurane INCLUSION CRITERIA: Patients belonging to ASA I and II Patients of age 18 to 64 years Surgeries done under general anesthesia requiring endotracheal intubation
Epistemonikos ID: 4216097b87b45c4fd80306b277b308fabc784c81
First added on: Oct 08, 2026