Effect of Sylimarin versus placebo on the reduction of liver complication of Teriflunomide in patients with multiple sclerosis

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2023
INTERVENTION: Intervention 1: Intervention group: Triflunomide tablet 14 mg daily plus silymarin tablet 140 mg twice daily for 2 months. Intervention 2: Control group: Triflunomide tablet 14 mg daily plus placebo tablet (starch) twice a day for 2 months. CONDITION: Multiple sclerosis. ; Multiple sclerosis PRIMARY OUTCOME: Liver and biliary function tests (including AST, ALT, ALP, bilirubin and GGT). Timepoint: Before the intervention and one and two months after the intervention. Method of measurement: By laboratory test. INCLUSION CRITERIA: Age 18 to 70 years Multiple sclerosis
Epistemonikos ID: 41d9e9ed6ab0a5432ef33dd1504f8e20e4ab3daa
First added on: Feb 20, 2024