Comparative Study of MMC Augmented Trabeculectomy Vs An Ologen Implant in Open Angle Glaucoma

Long-term intraocular pressure (IOP) control following trabeculectomy may be limited by filtration failure, because of scarring at the level of the conjunctiva–Tenon’s–episcleral interface,the scleral flap, its overlying episclera, or the internal ostium.1 Adjunctive anti-fibrotic agents such as 5-fluorourail or mitomycin C (MMC) have a potent inhibitory effect on postoperative scarring and a positive effect on surgical success rates.2,3 These agents inhibit fibroblastic proliferation in wound healing, thus preventing excessive scar tissue formation at the level of the subconjunctival plane, which may otherwise compromise aqueous flow and lead to surgical failure. The Ologen collagen matrix implant is a disc-shaped porcine derived biodegradable collagen matrix that has been developed to prevent excessive scarring after trabeculectomy. The purpose of this study was to compare the outcomes of trabeculectomy with OloGen implant and trabeculectomy with MMC and without implant in patients requiring glaucoma surgery for uncontrolled IOP in primary open angle glaucoma. Other outcomes measured were the number of postoperative medications used and any complications.