Endocrine Mucin Producing Sweat Gland Carcinoma Treated With Mohs Micrographic Surgery: A Systematic Review.

BACKGROUND: Endocrine Mucin Producing Sweat Gland Carcinoma (EMPSGC) is a low-grade, cutaneous adnexal neoplasm. It is believed to have a potential for local recurrence as well as distant metastases in rare cases. OBJECTIVE: This study's purpose is to compare recurrence rates and outcomes between EMPSGC undergoing Mohs micrographic surgery (MMS) and traditional surgical excision. METHODS: A comprehensive review of the literature was performed using the following keywords: "Endocrine Mucin Producing Sweat Gland Carcinoma" and/or "EMPSGC" and/or "Mohs Micrographic Surgery" and/or "MMS" and/or "wide local excision" and/or "excision." RESULTS: There were 17 articles and 27 patients identified between the two databases. The procedures included 17 MMS and 13 surgical excisions. Patients treated with MMS typically had a lower incidence of recurrence (11.8%). In contrast, patients treated with surgical excision had a higher recurrence rate (46.2%). LIMITATIONS: This study is limited by the small number of cases identified in our literature search and the variability in follow-up duration among the cases. CONCLUSIONS: MMS demonstrated less recurrence of EMPSGC compared with surgical excision. Further research with large sample sizes would be beneficial in optimizing the surgical treatment approach for EMPSGC. CITATION: Wittmer A, Arora N, Shalabi MMK, et al. Endocrine mucin producing sweat gland carcinoma treated with Mohs micrographic surgery: a systematic review. J Drugs Dermatol. 2025;24(5):498-501. doi:10.36849/JDD.8713.