ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients (EPO-TRAUMA)

INTERVENTION: Epoetin alfa 4000IU Subcutaneously administered within 24 hours of injury. Additional dose of study drug on study day 8 if none of the withholding criteria are met. Study drug is withheld if the Hb concentration is greater than 120 g/L Intervention will be in major hospitals. CONDITION: Emergency medicine ‐ Other emergency care Injuries and Accidents ‐ Other injuries and accidents Trauma;Critical Illness; ; Trauma ; Critical Illness PRIMARY OUTCOME: Composite of death and severe disability (defined as WHODAS 2.0 >24%)[Six months] SECONDARY OUTCOME: Mortality ; [Hospital Discharge] INCLUSION CRITERIA: a) Are = 18 to = 75 years of age b) Are < 24 hours since primary traumatic injury c) Are invasively mechanically ventilated d) Are expected to stay in the ICU = 48 hours e) Have a haemoglobin not exceeding the upper limit of the applicable normal (ULN) reference range in clinical use at the treating institution f) Have written informed consent from legal surrogate according to local law