Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease

This trial is a randomized, parallel‐group, double‐blind, controlled clinical trial to compare intervention treatment (Per‐Young Eye Drops: preservative‐free 0.15% HA) against control treatment (AIM Artificial Tears: salt solution without 0.15% HA). All participants will be received Per‐Young Eye Drops (4 to 8 times per day) or AIM Artificial Tears (4 to 8 times per day) with 12 weeks. Two drugs are identical in appearance and order of administration will be double‐blind randomized. Primary endpoint: To compare the central tear meniscus height (TMHc) of treatment with preservative‐free 0.15% HA to the treatment with salt solution without 0.15% HA at 4 weeks.