The Intraoperative Landiolol for Intracranial Aneurysm Surgery Trials

INTERVENTION: Landiolol hydrochloride is continuously administered during the operation. Heart rate is maintained betweeb 60 and 80bpm. Landiolol hydrochloride is not used regardless of any heart rate. If necessary, other drugs such as diltiazem hydrochloride are allowed to use. CONDITION: Tachyarrhythmia PRIMARY OUTCOME: The incidence of cardiovascular event SECONDARY OUTCOME: Heart rate; Plasma cytokine; Markers of tissue damage (blood nitrotyrosine, urine 80HdG, S100‐beta); Incidence of delayed ischemic neuronal deficits; Neurological prognosis after three months INCLUSION CRITERIA: 1. Patients undergoing ruptured intraclanial aneurysm surgery. 2. The interval from the onset of symptoms until the operation is less than 48 hours. 3.Heart rate is 90 or more beats per minute before the operation.