Does N-Acetylcysteine (Parvolex®) prophylaxis reduce the incidence of renal impairment after onpump Coronary Artery Bypass Graft surgery? A prospective randomised controlled trial

INTERVENTION: For both groups, there will be no change in routine anaesthetic/surgical or post operative management. The intervention group will be administered 2 g N‐Acetylcysteine on the night before surgery (oral), 2 g at induction of anaesthesia (intravenous [IV]) and 2 g IV on the morning of first post operative day. The control group will receive placebos at the same time as the intervention group. Patients will be followed up until discharge. As of 07/02/2012, the trial was stopped in September 2010 due to problems with recruitment and the delay resulted in the trial being out of date. CONDITION: Renal impairment ; Urological and Genital Diseases ; Renal diseases PRIMARY OUTCOME: Creatinine clearance and serum creatinine levels on second and fifth post operative day and on discharge. SECONDARY OUTCOME: Length of Intensive Care Unit (ICU) stay. INCLUSION CRITERIA: 1. Patients undergoing elective coronoray artery bypass surgery (onpump) at Wythenshawe Hospital 2. Aged 21 ‐ 80 years