Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.

The requested reference [520d61a591c8417030388c016b8ab8e7bb80de88] no longer exists in our database. It has been replaced by the current reference: [73ea625f132c457ab3df5dcf6a178f01cadafd7c]

Authors Wolf DG, Yaniv I, Ashkenazi S, Honigman A -More
Category Primary study
JournalAntimicrobial agents and chemotherapy
Year 2001
Links DOI, Pubmed, PMC
Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.
Epistemonikos ID: 3b7af1b83c718488b875fe0365e8692d24c973de
First added on: Nov 24, 2021