A clinical study comparing 5-Fluorouracil and Modified Carnoys Solution for prevention of Odontogenic Kerarocyts recurrence along with evalution of nerve paresthesia and wound infection rates, having a minimum follow up for 6 months

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: 5‐Fluorouracil: 5‐Flurouracil dressing placed in surgically managed cyst cavity Control Intervention1: Modified Carnoys solution: Dressing with Modified Carnoys solution placed in surgically managed cystic lesions CONDITION: PRIMARY OUTCOME: To evaluate recurrence between the two groupsTimepoint: 0, 1 month, 3 months, 6 months SECONDARY OUTCOME: To evaluate post‐operative wound healing and dehiscence in two groups ; a)Soft Tissue 3rd Day, 7th Day, 3‐Month interval ; b)Hard Tissue (Bone) in a 6‐Month interval ; To evaluate extra‐oral swelling by the Gabka and Matsumara System ; To evaluate neurosensory dysfunction in two groups by Light Touch Test with Cotton wisp or, Monofilament. ; To evaluate the pain scale in two groups by the VAS System ; Timepoint: 0, 1 month, 3 months, 6 months INCLUSION CRITERIA: Medically fit patients including both sexes, with no significant habits, without local inflammation or other pathosis will be included. Patients with histopathologically proven OKC (with incisional biopsy report) involving the mandible. Patients who are ready to sign informed consent for their participation in the study will be included. ASA (American Society of Anaesthesiologists classification) class I & class II will be included. ASA Class I = A normally healthy individual (no physiological, physical, or psychological abnormalities). ASA Class II = A patient with mild systemic disease without limitation of daily activities.
Epistemonikos ID: 3b796897b04efbb8c75568000126275e52a70a19
First added on: Oct 08, 2026