RM1 Project 1 - tAN Naloxone

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2023
This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute transcutaneous auricular neurostimulation (tAN) intervention are mediated through a release of endogenous opioids. Analgesic effects of four various stimulation interventions will be measured (auricular vagus, auricular trigeminal, combination, or sham) while varying the type of intravenous (IV) infusion (either naloxone or saline) a participant is administered to determine whether the analgesic effects are mitigated by pharmacological opioid receptor blockade.
Epistemonikos ID: 3b72657bda377e55921cf15491d778aa22884851
First added on: May 13, 2024