Diagnostic Performance and Safety of 18F-NaF-PET/CT in Bone Metastases Compared With 99mTc⁃MDP-BS±SPECT

The goal of this clinical trial was to assess the diagnostic performance and safety of Sodium Fluoride F‐18 Positron Emission Tomography / Computed Tomography (18F‐NaF‐PET/CT) in bone metastases of malignant tumors compared with Technetium[99mTc] Methylenediphosphonate Bone Scintigraphy ± Single Photon Emission Computed Tomography (99mTc‐MDP‐BS±SPECT). The enrolled subjects were randomly assigned to two sequences A and B at a ratio of 1:1. Within 7 days, 18F‐NaF‐PET/CT and 99mTc‐MDP‐BS±SPECT bone imaging were performed alternately. The sensitivity, specificity, positive and negative predictive value of 18F‐NaF‐PET/CT and 99mTc‐MDP‐BS±SPECT were calculated respectively based on the diagnostic data of standard of truth.