Early Discontinuation of Empirical Antifungal Therapy and Biomarkers

Patients requiring EAT will be randomly assigned to: ‐ intervention group: a strategy in which EAT duration is determined by (1,3)‐B‐Dglucan and mannan serum assays, performed on day 0 (day of EAT initiation) and day 3. Early stop recommendation, provided before day 7, will be determined using an algorithm based on the results of biomarkers. ‐ control group: a routine care strategy, based on international guidelines, which recommend 14 days of treatment for patients without subsequent proven ICI, and who improve under antifungal treatment, or less in other situations.