Breast cancers detected in only one of two arms of a tomosynthesis (3D-mammography) population screening trial (STORM-2)

The prospective 'screening with tomosynthesis or standard mammography-2 (STORM-2)' trial compared mammography screen-reading strategies and showed that each of integrated 2D/3D-mammography or 2Dsynthetic/3D-mammography detected significantly more breast cancers than 2D-mammography alone. This short report describes 13 (from 90) cancers detected in only one of two parallel double reading arms implemented in STORM-2. Amongst this subset of cases, the majority was invasive cancer <= 16 mm, mostly depicted as irregular masses or distortions. Furthermore, most were detected at 3D-mammography only and predominantly by one reader from double-reading pairs, highlighting that 3D-mammography may enable detection of cancers that are challenging to perceive at routine screening. (C) 2017 Elsevier Ltd. All rights reserved.