Endoscopic treatment of acute simple appendicitis, a randomized, open, parallel, controlled single-center clinical trial

INTERVENTION: endscopic treatment:endscopic treatment;Surgical group:surgery; CONDITION: acute simple appendicitis PRIMARY OUTCOME: cure rate;hospital stay;hospitalization cost; SECONDARY OUTCOME: abdominal pain;abdomianl tenderness;rebound tenderness;muscle tension;fever;diarrhea;mucous stool;blood, urine and stool routine examination;blood biochemical index;abdomen ultrasound;colonscopy;the satisfaction of patient; INCLUSION CRITERIA: 1. aged from 18 to 65; 2. male and female; 3. onset time less than 48 hours; 4. Clinical manifestations of metastatic right lower abdominal or acute onset of right lower quadrant pain; McBurney point tenderness; or accompanied by muscle tension; 5. temperature<39.0 degree C; 6. WBC<20×10^9/L; 7. Stable vital signs: respiratory smooth (18‐24 beats/min), pulse strong (60‐110 beats / min), normal blood pressure (90‐120/60‐80mmHg); 8. No previous history of chronic cardiaclungbrainkidey and lvier diseases; 9. Signed informed consent to participate in this study.