Impact of Polyphenol Rich Indian Diet in patients with Fatty Liver

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: Polyphenol Rich Indian Diet: Polyphenol Rich Indian Diet sourcing upto 2500mg Polyphenols from dietary sources and Amla Powder. Control Intervention1: Polyphenol Rich Indian Diet: Polyphenol Rich Indian Diet sourcing upto 1500mg Polyphenols from dietary sources only Control Intervention2: Standard of Care: Standard of Care dietary pattern as provided by the Clinical Dietitian CONDITION: Health Condition 1: K760‐ Fatty (change of) liver, not elsewhere classified PRIMARY OUTCOME: To evaluate the changes in the Hepatic Steatosis Index at 6 monthsTimepoint: Baseline and 6 months SECONDARY OUTCOME: To assess cardiometabolic risk parameters such as Fasting plasma glucose, HbA1c, and serum lipid profile (Total cholesterol, LDL cholesterol, Triglycerides).Timepoint: Baseline and 6 months To assess the levels of inflammatory markers (IL‐6, Tumour necrosis factor‐alpha, hs‐CRP)Timepoint: Baseline and 6 months To correlate the presence of Steatosis with the body composition and physical activity status in patients with MASLD.Timepoint: Baseline and 6 months To record and evaluate the changes in liver enzymes (AST, ALT, GGT) and Intrahepatic Fat percent (MRI‐PDFF based).Timepoint: Baseline and 6 months INCLUSION CRITERIA: Patients aged 19‐65 years presenting to the outpatient liver clinic diagnosed with Metabolic associated steatotic liver (MASLD) disease will be enrolled in the study. Diagnosis of MASLD will be based on history, clinical findings, biochemical tests, imaging (MR Elastography) as whichever applicable. Aetiology of MASLD will be based on the history of lifestyle pattern, alcohol intake and features of metabolic syndrome.
Epistemonikos ID: 384b931e9d3d74cdfd040fe885faddb6d52d74ba
First added on: Oct 08, 2026