Compression of efficacy of topical phenytoin, honey and combination of honey with triglyceride tree nitrate on wound healing in rat

Background: Drugs and many traditional medicine compounds have long been used to accelerate the wound healing process. We investigated the effect of honey and nitroglycerin on wound healing. Materials and Method: The rats were randomly divided into 4 groups of Control, Nitroglycerin, Honey, and Phenytoin. After the injury of animals in each group, except for the control group, the dressings with related-drugs were opened-up daily.T he wound was accessed on days 1,4,8,12,16, and when it was completely healed. At the same time, a sample of wound was collected at each stage for histological examination. Results: wound healing period in honey and nitro glycerin groups was significantly shorter than control and phenytoin groups. improvement in inflammation and epithelial formation, were not statistically significant. Conclusion: It seems that honey and nitroglycerin cause faster wound healing. However, more studies are needed to investigate the effects of these drugs as well as their synergistic use on the wound.