Loxoprofen versus diclofenac potassium in post-dental extraction pain relief and side effects

INTERVENTION: Eligible patients after tooth extraction were randomized to the study interventional groups (Rapidus or Roxonin) by means of drawing lots and intervention and control were coded as A or B. The codes of the drugs were kept by an independent monitor and were unveiled until all data underwent analyses. The researcher, the clinicians, and patients were blinded to the codes of the drugs A and B during the course of the study. When the participant opens the envelope, he/she found the instruction of how to take the medicine as the manufacture instructed. Medicine was taken for three days and pain assessed by VAS after 6 hours and then every 12 hours for three days. CONDITION: Pain after tooth extraction ; Oral Health PRIMARY OUTCOME: Pain after tooth extraction by using VAS (visual analogue scale) , the timepoint was after 6 hours of tooth extraction and every 12 hours for three days. SECONDARY OUTCOME: Side effects over the trial period (three days) INCLUSION CRITERIA: 1. Age 18‐70 years old . 2. Literate people (speaking, reading and writing Arabic or English). 3. Healthy or with controlled systemic disease as recommended by the American Society of Anesthesiologists and had no risk from the administration of LA with adrenaline (hyperthyroidism).