Reduction of wound swelling using herbal medicine, a combination of keishibukuryogan and jidabokuippo, in patients undergoing craniotomy: a randomized controlled trial

INTERVENTION: Patients with herbal medicine 1. Receiving keishibukuryogan (7.5g per day) from 2 days prior surgery to the day before surgery. 2. After confirming that consciousness and swallowing on the 1st postoperative day return to preoperative level, Receiving jidabokuippo (7.5g per day) in addition to keishibukuryogan. Patients with herbal medicine 1. Not receiving herbal medicine CONDITION: unruptured cerebral aneurysm PRIMARY OUTCOME: Differences of thickness of soft tissues on skull displayed on computed tomography performed before and after surgery (the 4th and 7th postoperative days) INCLUSION CRITERIA: 1)Undergoing neck clipping through fronto‐temporal craniotomy for unruptured cerebral aneurysm in our institute. 2)Age:74 or less and 20 or more. 3) Possible to administer jidabokuippo and keishibukuryogan. 4)Obtaining informed consent.