Clinical Efficacy and Brain Network Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Treating Neuropathic Pain after Spinal Cord Injury

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Control group:Transcutaneous vagus nerve electrical stimulation (sham stimulation);Experimental group:transcutaneous auricular vagus nerve stimulation (active stimulation); CONDITION: Neuropathic Pain after Spinal Cord Injury PRIMARY OUTCOME: Short‐Form McGill Pain Questionnaire; SECONDARY OUTCOME: Activities of Daily Living (ADL) scale score;Somatosensory Evoked Potentials;Leeds Assessment of Neuropathic Symptoms and Signs;Interleukin‐6;Generalized Anxiety Disorder‐7 Score;Douleur Neuropathique 4 questions;Motor Evoked Potentials (MEP);Functional Near‐Infrared Spectroscopy (fNIRS);Patient Health Questionnaire‐9 (PHQ‐9);Chinese version of the World Health Organization Quality of Life Brief Scale (WHOQOL‐BREF); INCLUSION CRITERIA: 1.Meet the diagnostic criteria for NP, with motor and sensory dysfunction in the spinal cord innervated areas below the level of injury, and patient‐reported pain such as burning pain, allodynia, stabbing pain, etc; 2.Stable vital signs, clear consciousness, ability to express themselves clearly, and pain occurring after SCI; 3.No serious complications; 4.Patients have given informed consent and signed the informed consent form;
Epistemonikos ID: 34bd3a1c12f82894576533d27be8a2d293a7ac31
First added on: Aug 10, 2026