High dose Coenzyme Q10 and vitamin E therapy in Friedreich's ataxia

INTERVENTION: High doses of coenzyme Q10 / vitamin E vs Low doses of coenzyme Q10 / vitamin E CONDITION: Friedreich's ataxia ; Nervous System Diseases ; Friedreich's ataxia PRIMARY OUTCOME: Significant improvement in the rate of change in the International Cooperative Ataxia Ratings Scale (ICARS) scores over two years of the trial in the high dose versus the low dose treatment groups SECONDARY OUTCOME: 1. Rate of change in the kinetic, posture and gait, speech, ocular subscores of the ICARS; ; 2. Rate of change in the following: ; a. speech tests (PaTa repetition, speed of reading); b. upper limb coordination tests (hand clicker, modified peg board, hand target, BRAIN kinesia); c. lower limb coordination tests (foot target, box); d. cardiac tests (IVS, PWd and fraction shortening); e. activities of daily living scale INCLUSION CRITERIA: 1. Homozygous for the GAA expansion in the FRDA gene characteristic of the disease 2. Able and willing to attend the assessments over the trial period 3. Over 10 years of age at the start of the trial