Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia

The goal of this randomized clinical trial is to compare the effects of two doses ofaspirin, 75 mg and 150 mg, in pregnant women who are at high risk of developingpreeclampsia.The main question the study aims to answer is: 1. Does taking 150 mg of aspirin reduce the occurrence of preeclampsia more effectivelythan taking 75 mg of aspirin in pregnant women at high risk of preeclampsia? 2. Are there differences in stillbirth and newborn birth weight between the two aspirindoses?The study will include 224 pregnant women aged 18‐45 years who are between 11 and 14weeks of pregnancy and are identified as being at high risk for preeclampsia.Participants will be randomly assigned to one of two groups. ‐ Participants in the low‐dose group will take 75 mg of aspirin once daily at bedtime. ‐ Participants in the high‐dose group will take 150 mg of aspirin once daily atbedtime.Participants will continue their assigned aspirin dose until 36 weeks of pregnancy andwill be followed every 2 weeks until delivery.The study will record whether participants develop preeclampsia and whether stillbirthoccurs. The birth weight of each newborn will also be measured within 3 hours of birth.The study hypothesis is that 150 mg of aspirin will result in a lower incidence ofpreeclampsia than 75 mg of aspirin in pregnant women at high risk of preeclampsia.