Clinical Research on Modified Chaihu Jia Longgu Muli Decoction in the Treatment of Parkinson's Disease Complicated with Rapid Eye Movement Sleep Disorder

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Treatment Group:Basic treatment plus modified Chaihu Jia Longgu Muli Tang (Chaihu 10g, Huangqin 10g, Fbanxia 10g, Dangshen 10g, Dazao 12g, Shengjiang 6g, Longgu 30g, Muli 30g, Guizhi 10g, Fuling 15g, Shudahuang 3g, Daizheshi 10g; syndrome differentiation addition: add Tiansheng 6g for phlegm‐heat stirring wind type, add Danshen 15g for qi stagnation and blood stasis type, add Danggui 10g for qi and blood deficiency type, add Baishao 10g for liver‐kidney deficiency type, add Tusi zi 15g for yin‐yang deficiency type), one dose daily, decocted to 400ml, divided into two doses, warm intake, course of treatment 4 weeks;Control Group:Basic treatment (including Madopar, Pramipexole and other anti‐Parkinson's disease drugs), course of treatment 4 weeks; CONDITION: Parkinson's Disease Complicated with Rapid Eye Movement Sleep Disorder PRIMARY OUTCOME: Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) Score;Pittsburgh Sleep Quality Index (PSQI) Score;Polysomnography (PSG) Data; SECONDARY OUTCOME: Unified Parkinson's Disease Rating Scale Part III (UPDRS‐III) Score;Traditional Chinese Medicine Syndrome Score for Tremor;Serum Melatonin Level; INCLUSION CRITERIA: 1.Age >=18 years old and <=80 years old. 2.Patients who visited Huzhou Central Hospital and were diagnosed with Parkinson's disease combined with rapid eye movement sleep disorder. 3. Voluntarily participated in this study and signed the informed consent form. 4. Not taking any sedative‐hypnotic or antipsychotic drugs for treatment. 5. Hoehn ‐Yahr grade 1‐3.
Epistemonikos ID: 33ef1b33c1a0813ca8b6065ae8e224af092767ef
First added on: Mar 07, 2026