A Trial to Study the Effects of Ginseng and Cordyceps on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide

This study is a double‐blind, randomized, parallel group, three‐arm, placebo‐controlledtrial of seventy‐five (75) apparently healthy male and female participants to berecruited at a single investigational center in Northeast Ohio (i.e., The Center forApplied Health Sciences). The study will assess the potential benefits of four weeks ofsupplementation with 300 mg Ginseng or 1 gram Cordyceps Militaris (vs. placebo).Participants will attend 3 study visits. During Visit 1, participants will be screenedfor participation (i.e., medical history, routine blood work, background baseline dietand familiarization protocol will be completed). During Visit 2 (Day 0) and Visit 3 (Day30) participants will complete subjective baseline testing including questionnaires thatassess recovery, mood, energy, fatigue, and quality of life. They will complete a VO2 maxtest, a TTE test, isometric mid‐thigh pull, and have their handgrip strength assessed.They will also be tested for changes in circulating nitrates/nitrites (NOx), circulatoryefficiency (oxygen pulse), and lactate kinetics (production and clearance).Comprehensive side effect profile/ adverse event monitoring will take place throughoutthevstudy duration. The study will be conducted following ICH‐GCP guidelines to ensuresubject safety and scientific integrity of the data.