7-day hemodynamic response to carvedilol combined with isosorbide mononitrate (ISMN) versus carvedilol alone in cirrhotic patients: a randomized controlled trial

INTERVENTION: A:Carvedilol, orally taken for 7 days. The initial dosage is 12.5mg once daily, and the dosage is modulated for the target that the heart rate reduces below 55 per minute or the reduction > 20% of the baseline heart rate. Keep the systolic blood pressure =90mmHg. Once hypotension occurs, reduce the dosage at once and drug withdrawl is required if necessary. ;B:Carvedilol+Isosorbide Mononitrate Sustained Release Tablets, orally taken for 7days. The initial dosage of carvedilol is 12.5mg once daily, and ISMN 30mg daily. The dosage is modulated for the target that the heart rate reduces below 55 per minute or the reduction > 20% of the baseline heart rate. once hypotension occurs, reduce the dosage at once and drug withdrawl is required if necessary. ; CONDITION: portal hypertension PRIMARY OUTCOME: HVP; SECONDARY OUTCOME: diameter of portal vein;mean artery pressure;velocity of portal vein flow;blood flow of portal vein;heart rate; INCLUSION CRITERIA: 1. Male and female aged 18 to 75 years old; 2. Able and willing to provide signed informed consent; 3. Cirrhosis; 4. Presence of endoscopcally proven esophagogastric varices; 5. Baseline hepatic venous pressure gradient(HVPG) >=10mmHg.