The Effect of Zinc Supplementation on Expression of Zinc Transporters in Healthy Individuals

INTERVENTION: Zinc Chelate 220mg (22mg elemental zinc), one tablet per day for 21 days administered orally (TGA registry ‐ ARTG 128690). Compliance will be checked by tablet return and plasma zinc levels. CONDITION: Zinc transport PRIMARY OUTCOME: Inflammation (CRP, IL‐1, IL6, TNF‐alpha) by rate nephelometry or similar Zinc transporter mRNA expression in peripheral blood mononuclear cells by real‐time quantitative PCR SECONDARY OUTCOME: Plasma zinc by ICP‐MS INCLUSION CRITERIA: ‐ Adults, age 18‐65 y ‐ Have not been diagnosed with major illness