Therapeutic effect of herbal formulation Hypericum perforatum with antidepressant drug

INTERVENTION: Intervention 1: Tricyclic antidepressant with average dose, as well as Hypericum Perforatum (a herbal formulation), three times a day 6 weeks. Intervention 2: Tricyclic antidepressant with average dose, as well as placebo, three times a day 6 weeks. Placebo Treatment ‐ Drugs Tricyclic antidepressant with average dose, as well as Hypericum Perforatum (a herbal formulation), three times a day 6 weeks Tricyclic antidepressant with average dose, as well as placebo, three times a day 6 weeks CONDITION: Condition 1: Moderate depression. Condition 2: Mild depression. ; Moderate depressive episode ; Mild depressive episode F 32.0 Mild depressive episode Moderate depressive episode PRIMARY OUTCOME: Improvement of apetite. Timepoint: 3 weeks. Method of measurement: clinical interview. Improvement of sleep. Timepoint: 3 weeks. Method of measurement: clinical interview. SECONDARY OUTCOME: Treatment of depression. Timepoint: 3 weeks. Method of measurement: Beck Rating Scale for Depression. INCLUSION CRITERIA: INCLUSION CRITERIA: Major depressive disorder diagnosed by a psychiatrist based on DSM‐IV‐TR criteria, age range between 18‐55 years, filling the consent form, mild or moderate severity of depression Exclusion Criteria: Pregnancy, breast feeding, organic or neurological disorder featuring both clinically, Axis II psychiatric disorder, presence of simultaneous psychiatric disorder diagnosis in axis I, using alcohol and other addictive substances other than nicotine and caffeine in a one‐month past, exacerbation of symptoms of severe depression or psychotic disorders, Signs that require hospitalization and emergency action such as suicidal thoughts and behaviors, Not receiving ECT over three months prior to the study, any particular sensitivity to plant grass herbal tea, consumption of medicine such as lithium, anticonvulsants, sumatriptan, Al Biped, serotonin‐reuptake inhibitors, buspirone, Argo compounds, Selegiline, stimulants, anti‐congestive, contraceptives,