Effect of everyother day dosing regimen of latanoprost on intraocular pressure

INTERVENTION: Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 1) and every other day dose in the other eye (group 2) at month1. Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 2) and every other day dose in the other eye (group 1) at month 2. Intervention 1: Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 1) and every other day dose in the other eye (group 2) at month1. Intervention 2: Eyedrop latanoprost 0.005% once daily at 9 PM in one eye (group 2) and every other day dose in the other eye (group 1) at month 2. Treatment ‐ Drugs CONDITION: Glaucoma. ; Ocular Hypertension,primary open angle glaucoma H40.0 , H4 Ocular Hypertension,primary open angle glaucoma PRIMARY OUTCOME: Intraocular pressure (IOP). Timepoint: 24 hours before instillation of latanoprost, baseline IOP was measured 3 times ,at 9AM,4PM,and 9PM and again after one and two months of drug usage,based on assigned protocol of drug instillation,were measured at the same time points. Method of measurement: Calibrated Goldmann applanation tonometer. SECONDARY OUTCOME: Side effects related to drug. Timepoint: At each time visit after instillation of drug ,during 2‐month period of study. Method of measurement: Anterior segment exam by slit lamp biomicroscopy,posterior segment exam by funduscopy lenses, visual acuity test by Snellen chart and patients own description of side effects like significant Itching,redness and burning sensation. INCLUSION CRITERIA: The inclusion criteria are: Age =30 years, IOP =22 and =32 mmHg without any IOP lowering medication, cup to disc ratio =0.6, mean deviation of = ‐6 decibel in perimetry and open angles on gonioscopy. Patients with a history of prior ocular surgery, uveitis, herpetic keratitis, and allergy to latanoprost are excluded