The effect of Isosorbide Mononitrate on induction success

INTERVENTION: Intervention 1: Isosorbide Mononitrate, 40mg, vaginal for the caces. Intervention 2: Placebo for the control group. Isosorbide Mononitrate, 40mg, vaginal for the caces Placebo Placebo for the control group Treatment ‐ Drugs CONDITION: Other assisted single delivery Other assisted single delivery. ; Other assisted single delivery PRIMARY OUTCOME: Bleeding volume in labor and post partum. Timepoint: Control of labor course. Method of measurement: Based on Documented data. Delivery mode. Timepoint: Post partum. Method of measurement: Based on Documented data. Hospitalization duration and active phase initiation. Timepoint: Control of labor course. Method of measurement: Based on Documented data. Labor course. Timepoint: Hospitalization to delivery. Method of measurement: Based on Documented data. SECONDARY OUTCOME: Newborn apgar score. Timepoint: Immediately after delivery. Method of measurement: Based on documented data. NICU requirement. Timepoint: Post partum. Method of measurement: Based on documented data. The occurance of maternal headache. Timepoint: Control during labor & delivery. Method of measurement: Based on documented data. The ocurrance of tachysystol/hypersystol and hyperstimulated syndrome. Timepoint: FHR monitoring during labor. Method of measurement: Based on documented data. The rate of maternal palpitation. Timepoint: During labor. Method of measurement: Based on documented data. INCLUSION CRITERIA: The INCLUSION CRITERIA: 1‐single pregnancy, 2‐ cephalic presentation, 3‐ Bishop Score =6, 4‐normal AFI>5, 5‐ regular FHR, 6‐ intact membrane, 7‐ gestational age =37 weeks. Exclusion criteria are: Uterine contraction (=3 contraction 45’’ in 10 minutes) previous mymomectomy, history of headache, intolerance IMN, cardiopulmonary disease, vaso previa or placenta previa, cord prolepses, classic incision or previous myomectomy, irregular FHR, multiple pregnancy, macrosomia, polyhydramious, severe preeclampsia, maternal short stature.