A randomized, double-blind, controlled clinical trial of Duopi Yin in the treatment of chronic refractory urticaria

INTERVENTION: Test group:Take duopiyin granules and simulation of desloratadine citrate capsules;control group:Take simulation of duopiyin granules and desloratadine citrate capsules; CONDITION: Chronic urticaria PRIMARY OUTCOME: weekly urticaria activity scores; SECONDARY OUTCOME: chronic urticaria quality of life questionnaire;Urticaria Control Test; INCLUSION CRITERIA: Only those who meet all of the following items can join the group: 1) Comply with the diagnostic criteria of chronic refractory urticaria in Chinese and Western medicine; 2) Men and women aged 18‐65; 3) The course of disease lasts more than 6 months; 4) The patient who has been treated with second‐generation antihistamines for more than 2 weeks in the past si Xmonths cannot be completely controlled; 5) In recent half a year, the syndrome differentiation of traditional Chinese medicine was wind cold syndrome, wind heat syndrome or blood deficiency and wind dryness syndrome. After treatment by syndrome differentiation, the improvement of skin lesions was not obvious after 2 weeks of regular medication; 6) Participate in the study voluntarily and sign the informed consent; 7) UAS7=16, and UAS=4 assessed by doctors at least once before enrollment 1 week.