[Low-dose consecutive intra-arterial infusion of CDDP to treat advanced cervical carcinoma: usefulness of a vascular access device with alteration of intrapelvic blood flow].

Percutaneous transarterial implantation of a vascular access device (VAD) was used to treat advanced cervical carcinoma in 12 patients (IIb 3, IIIb 5, IVa 4). After altering intrapelvic flow by embolization under pelvic angiography, a 5 F catheter was placed in the internal iliac artery on the side of tumor dominance. RI angiography with 99mTc-MAA via the VAD showed 99% higher accumulation in the anterior division than in the posterior division of the pelvis. Consecutive infusion of cisplatin, 12.5 mg/body, via the VAD showed less toxicity than systemic chemotherapy. Overall response rate was 75% (CR 4, PR 5, NC 3). Curative surgical treatment was successful in nine of these 12 patients. This technique was evaluated to be effective for treatment of advanced cervical carcinoma.