Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis

The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers, particularly C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR). The main questions are: * How accurately can Pro-ADM distinguish patients with acute appendicitis from healthy controls? * How does the diagnostic performance of Pro-ADM compare with that of CRP and NLR? * Can Pro-ADM help predict complicated acute appendicitis? Researchers will compare adults undergoing appendectomy for acute appendicitis with healthy individuals attending outpatient clinics for routine evaluations. Participants will: * Provide information about their medical history and clinical characteristics. * Undergo blood sampling for Pro-ADM measurement. * Have relevant routine laboratory and imaging results recorded. A total of 400 participants will be enrolled. Clinical care and treatment decisions will follow standard medical practice.