IRE After Chemotherapy for Locally Advanced Pancreatic Cancer

This is a prospective, randomized, controlled, exploratory Phase II clinical study.Approximately 60 eligible patients with locally advanced pancreatic cancer who havereceived three cycles of chemotherapy induction and have non‐progressive disease will beenrolled. All patients must be considered unresectable by MDT review and must providewritten informed consent. Participants will be randomized 2:1. Forty patients willundergo open IRE followed by continuation of the original chemotherapy regimen; twentypatients will continue the original treatment regimen alone. OS, PFS, tumor response,QoL, safety, and postoperative outcomes will be observed.