Reducing pain and discomfort during and after bone marrow aspiration

INTERVENTION: Group 1: midazolam 7,5mg, oral, single dose AND morphine 10mg, oral single dose Group 2: lorazepam 1mg, oral single dose AND paracetamol 1000mg, oral, single dose CONDITION: Bone marrow cells, Pain, Anxiety ; ; PRIMARY OUTCOME: ‐Visual Analogue Scale (VAS) for pain, directly after the procedure; ; ‐ Visual Analogue Scale (VAS) for anxiety, fear for a next bone marrow aspiration and biopsy measured two weeks after the procedure SECONDARY OUTCOME: ‐ Fear of Pain Questionnaire‐III ; ; ‐ VAS for pain and anxiety at other moments than described at the main study parameters ; ; ‐ VAS for discomfort ; ; ‐ Possibility to follow instructions during the procedure INCLUSION CRITERIA: 1. Patients with an indication to undergo a first bone marrow aspiration in MC Slotervaart 2. Age > 18 years 3. Patient is capable to give informed consent