Celecoxib and depression

INTERVENTION: Cap fluoxetine 40 mg/day plus Cap. placebo as control group for 6 weeks Capsule Fluoxetine 40 mg/day plus Capsule Celecoxib 400 mg/day (200 mg bid) as intervention group for 6 weeks Intervention 1: Capsule Fluoxetine 40 mg/day plus Capsule Celecoxib 400 mg/day (200 mg bid) as intervention group for 6 weeks. Intervention 2: Cap fluoxetine 40 mg/day plus Cap. placebo as control group for 6 weeks. Treatment ‐ Drugs CONDITION: Depressive episode Depressive episode. ; Depressive episode PRIMARY OUTCOME: Severity of depression. Timepoint: Baseline and weeks 2,4 and 6. Method of measurement: Hamiltion Depression Rating Scale 17‐Item. INCLUSION CRITERIA: INCLUSION CRITERIA: Presence of Major Depressive Disorder based on DSM‐IV criteria, Baseline Hamilton Depression Rating Scale (HAM‐D) (17‐item) score of at least 18. Exclusion criteria: Presence of Psychosis, any diagnosis in Axis I and II, Receiving psychotropic medications, receiving any antidepressants during past one month or ECT in past two months, Presence of hypothyroidism or cardiovascular problems