Arterial oxygenation targets in Intensive Care patients

INTERVENTION: The conservative oxygenation arm will be targeted at PaO2 55‐80 mmHg (7.3‐10.7 kPa) and/or SpO2 91‐94% and the conventional oxygenation arm will be targeted at PaO2 between 110‐150 mmHg (14.7‐20 kPa) and/or SpO2 >96%. CONDITION: Intensive Care (IC) patients, Mechanical ventilation, Oxygenation targets ; ; PRIMARY OUTCOME: All‐cause mortality on day 28 after randomisation SECONDARY OUTCOME: The number of days alive and free from ventilation at day 28 after admission to the intensive care unit (ventilator‐free days), ; ; ICU‐mortality and in‐hospital mortality ; ; ICU length of stay (LOS), hospital LOS ; ; Organ failure (daily) ; ; Reintubation rate ; ; Cost of hospitalization ; ; Ischemic events; myocardial, intestinal, cerebral or peripheral ; ; Delirium ; ; Blood stream infection and respiratory tract infection ; ; Surgical site infection ; ; Re‐admission within 28 days ; ; ; ; Long term follow‐up: ; ; Quality of life at 6 and 12 months after randomisation ; ; Patient opinion of research and consent in the emergency setting at 6 months after randomisation ; INCLUSION CRITERIA: Age ¡Ý 18 years Admission to an ICU participating in this study Need for intubation and mechanical ventilation An expected mechanical ventilation time of 24 hours or longer Inclusion within 2 hours after start of invasive ventilation in the study ICU or if previously intubated and ventilated within 2 hours after admission to the study ICU