Palifermin After Haploidentical PBSCT

Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2007
This is a double blind, placebo controlled clinical trial, where patients with an advanced form of blood cancer are treated with haploidentical allogeneic peripheral blood progenitor cell (PBPC) transplant after which they are randomised to receive either placebo or a keratinocyte growth factor (Palifermin or Kepivance®). The function of Kepivance® is to stimulate the growth of epithelial cells. This drug has also been suggested to have an ability to help improve the reconstitution, or development, of the immune system after the transplantation. The hypothesis is that the patients T-cell dependent humoral immune response to recall antigen (PrevenarTM) will be higher in in palifermin treated patients than in the placebo control group
Epistemonikos ID: 2d88f998abc52aee47ed05c04c8d71c4d4d3c17b
First added on: Jan 21, 2022